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Dr. Fairolniza Mohd Shariff

Fairolniza

Academic qualifications

Ph.D., Universiti Putra Malaysia, Malaysia

 

Research interest:

I am always fascinated by protein structures, protein interactions and stabilization. I have focused my fascinatination into three main areas:

  1. Understanding the relationship between the molecular structure of a protein and the conformational changes that control its function as catalysts and inhibitors.
  2. Learning how the protein can be stabilized .
  3. Developing and designing ‘new enzymes’ with novel and enhanced characteristics.

The current proteins of interest include lipases, laccases, carbonic anhydrases and plant defensin. I aim to explore a new world of proteins to address challenges in medicine, environment, energy, and technology.

Selected publications:

1. Bukhari, N, Leow, A.L.T., Rahman, R.N.Z., Shariff, F.M. (2020). Single Residue Substitution at N-Terminal Affects Temperature Stability and Activity of L2 Lipase. Molecules 25 (13): 3433 doi.org/10.3390/molecules25153433

2. Morsy, S.A.G.Z., Tajudin, A.A., Ali, M.S.M., Shariff, F.M. (2020) Current development in decolorization of synthetic dyes by immobilized laccases. Frontiers in Microbiology 11: 2350 doi.org/10.3389/fmicb.2020.572309

3. Sani, H.A. Shariff, F.M., Rahman, R.N.Z.R., Leow, A.L.T. and Salleh, A.B. (2018) The Effects of One Amino Acid Substitutions at the C-Terminal Region of Thermostable L2 Lipase by Computational and Experimental Approach. Molecular Biotechnology 60 (1): 1-11 https://doi.org/10.1007/s12033-017-0038-3

4. Sadek, M.M., Barlow, N., Leung, E.W.W., Williams-Noonan, B.J., Yap, B.K., Shariff, F.M., Caradoc-Davies, T.T., Nicholson, S.E., Chalmers, D.K. Thompson, P.E., Law, R.H.P., Norton, R.S. (2018) A cyclic peptide inhibitor of the iNOS–SPSB protein–protein interaction as a potential anti-infective agent. ACS chemical biology 13 (10): 2930-2938 doi.org/10.1021/acschembio.8b00561

ORCID ID
https://orcid.org/0000-0001-7586-4784

 

Google Scholar
https://scholar.google.com/citations?user=1-q3xMAAAAAJ&hl=en          



E-mail: fairolniza@upm.edu.my
Kemaskini Terakhir : Mon, 26 Apr 2021 (GS58189)