Assoc. Prof. Dr. Normi Mohd Yahaya
Academic qualifications:
Ph.D., Universiti Sains Malaysia, Malaysia
Research interest:
My current research interest involves investigating the structures and functions of bacterial hypothetical proteins, particularly those that are involved in antibiotics degradation, designing and utilizing peptides as inhibitors of metallo-beta-lactamase enzyme which has been implicated in conferring antimicrobial resistance in bacterial pathogens. In addition to this, my research also embarks on engineering bacterial chitinase for potential application in the agricultural sector. The research is multi-faceted and multi-disciplinary in nature, which involves the use of bioinformatics, in silico molecular simulation, protein biochemistry and X-ray crystallography platforms.
Selected publications:
1. Selvaraju, G., Leow, T. C., Salleh, A. B., & Normi, Y. M. (2020). Design and Characterisation of Inhibitory Peptides against Bleg1_2478, an Evolutionary Divergent B3 Metallo-β-lactamase. Molecules, 25(24), 5797. doi:10.3390/molecules25245797
2. Oyeleye, A. O., Mohd Yusoff, S. F., Abd Rahim, I. N., Leow, A. T. C., Saidi, N. B., & Normi, Y. M. (2020). Effective refolding of a cysteine rich glycoside hydrolase family 19 recombinant chitinase from Streptomyces griseus by reverse dilution and affinity chromatography. PLOS ONE, 15(10), e0241074. https://doi.org/10.1371/journal.pone.0241074
3. Oyeleye, A., & Normi, Y. M. (2018). Chitinase: diversity, limitations, and trends in engineering for suitable applications. Bioscience Reports, 38(4), BSR2018032300. https://doi.org/10.1042/bsr20180323
4. Tan, S. H., Normi, Y. M., Leow, A. T. C., Salleh, A. B., Murad, A. M. A., Mahadi, N. M., & Rahman, M. B. A. (2016). Danger lurking in the “unknowns”: structure-to-function studies of hypothetical protein Bleg1_2437 from Bacillus lehensis G1 alkaliphile revealed an evolutionary divergent B3 metallo-beta-lactamase. Journal of Biochemistry, mvw058. https://doi.org/10.1093/jb/mvw058
ORCID ID
https://orcid.org/0000-0003-0707-7361
Google Scholar
https://scholar.google.com/citations?hl=en&user=wy1WJkkAAAAJ&view_op=list_works&sortby=pubdate
E-mail: normi_yahaya@upm.edu.my