Assoc. Prof. Dr. Adam Thean Chor Leow
Academic qualifications
Ph.D., Universiti Putra Malaysia, Malaysia
Research interest:
My research focuses on improving or changing the characteristics of enzymes such as lipases, phytases and plastics degrading enzymes for thermal, solvent and pH stabilities using protein engineering approaches to overcome the limitation of biocatalysts for industrial, agricultural and environmental applications. Structure based drug discovery is also focused to search for potential inhibitors with antibacterial properties. Therefore, in silico molecular dynamics simulations and X-ray crystallography are also undertaken to understand the behaviors of protein under particular environments and protein-ligand interactions to give insights into protein tailoring and drug discovery.
Selected publications:
1. Aris, S.N.A.M, Rahman, M.Z.A., Rahman, R.N.Z.R.A., Ali, M.S.M., Salleh, A.B. and Leow, T.C. (2021). Identification of potential riboflavin synthase inhibitors by virtual screening and dynamics simulation studies. Journal of King Saud University-Science, 33(2), 101270.
2. Nezhad, N.G., Rahman, R.N.Z.R.A., Normi, Y.M., Oslan, S.N., Shariff, F.M. and Leow, T.C. (2020). Integrative structural and computational biology of phytases for the animal feed industry. Catalysts, 10(8), 844.
3. Mazlan, S.N.H.S., Ali, M.S.M., Rahman, R.N.Z.R.A., Sabri, S., Jonet, M.A. and Leow, T.C. (2018). Crystallization and structure elucidation of GDSL esterase of Photobacterium sp. J15. International Journal of Biological Macromolecules, 119, 1188- 1194.
4. Ang, T.F., Salleh, A.B., Normi, Y.M., Leow, T.C. (2018). In silico design of potentially functional artificial metallo-haloalkane dehalogenase containing catalytic zinc. 3 Biotech, 8 (7), 314.
5. Maiangwa, J., Ali, M.S.M., Salleh, A.B., Rahman, R.N.Z.R.A., Normi, Y.M., Shariff, F.M. and Leow, T.C. (2017). Lid opening and conformational stability of T1 lipase is mediated by increasing chain length polar solvents. PeerJ, 3341, 1-32.
ORCID ID
https://orcid.org/0000-0002-0280-7735
Google Scholar
https://scholar.google.com/citations?user=IsY753wAAAAJ&hl=en
E-mail: adamleow@upm.edu.my