Animal Model in Biomedical Research

Introduction

Programme Leader : 1. Profesor Dr Md Zuki bin Abu Bakar - Veterinary Anatomy and Biomaterials Name of Co-Researcher : 2. Profesor Dr Noordin Mohamed Mustapha - (Veterinary Pathology and Environmental Toxicology) 3. Assoc. Professor Dr Jalila Abu - (Avian Medicine) 4. Assoc. Professor Dr Goh Yong Meng - (Physiology) 5. Assoc. Professor Dr Shanthi Ganabadi - (Anatomy) 6. Dr Hezmee Mohd Noor - (Pharmacology) 7. Dr Gayathri Thevi Selvarajah - (Small Animal Medicine) 8. Dr Cheng Hui Cheng - (Anesthesiology) 9. Dr Loqman Mohamad Yusof - (Surgery) 10.Dr Intan Shameha Abd Razak - (Histology) Synopsis: During the last decades, animal models have become invaluable experimental tools to answer fundamental questions in basic and applied research. In addition, the growing demand for more sophisticated animal models has also become increasingly evident including transgenic animal model in research. Good state-of-principle knowledge about the enormous potential of second-generation conditional animal model technology will be beneficial for any researcher interested in using these experimental tools. The programme focuses on the use of animal models in biomedical studies which also includes biocompatibility tests of novel biomaterials in an orthopaedic research and also cancer research. The objectives of the programme are to improve animal models for research, to enhance and encourage the use of best animal model in biomedical research, and to promote the animal welfare awareness in research. Keywords: Animal model, biomedical, research Research Highlights: This programme was established with the main objective is to enhance the use of best animal model in biomedical study including biocompatibility tests of novel biomaterials in an orthopaedic research and also cancer research. The member of this research programme comprises of experience personnel in related disciplines; animal anatomy, physiology, biochemistry, pharmacology, toxicology, pathology, ethology, welfare and jurisprudence, small and large animal medicine and anesthesiology, surgery, radiology and imaging. The laboratories are well equipped and can support the need for the research activities. The University Veterinary Hospital (UVH) is the only well equips veterinary hospital in the region and can provide good facilities and support services for the research activities. The facilities and services provided by the center for laboratory animals research (CoMET) also support the need for the research. The programme has good networking with other institutional at national and international levels. The research programme has published more than 50 publications in CIJ and books/book chapters, not including the proceedings. The programme has secured 10 research grants from public and private sectors worth about RM1.5 million (2006-2011). About 40 postgraduate students (27 MS and 13 PhD) are now doing research under this programme and 30 students were graduated (15 MS and 15 PhD. Various laboratories, University Veterinary Hospital (UVH), Laboratory Animal Research Centre (CoMET) Current Projects: Therapeutic effects of calcium carbonate nano-crystals aragonite polymorph on bone cancer metastasis and drug delivery system. ScienceFund (MOSTI), RM230 000, Mei 2012 - April 2014 Development of Complement C5a and its Receptor (C5aR) as a Mammary Tumour Biomarker. ERGS (MOHE), RM195000 Sept 2011 - August 2013 Establishment of Mechanism of Tumour Regression Through Complement Mediated Inflammatory Reaction of C5a-C5aR Axis. ScienceFund (MOSTI), RM245 000, April 2012 - March 2014. Expression of Complement Anaphylatoxin 5A Receptor (C5aR) and Measurement of its Magnitude in Spontaneous Canine Tumours. RUGS, RM30 000, Oct 2011 Sept 2013 Expression of avian bone morphogenetic protein 2 and its osteogenesis effect in chicken model. RUGS, RM103,000.00, 2011-2013 Recent Publications: Kh Nurul Islam, Md Zuki Bin Abu Bakar, Md Eaqub Ali, Mohd Zobir Bin Hussein, Mustapha M. Noordin, M.Y. Loqman, Gaus Mial, Hanif Wahid and Uda Hashim (2013). A novel method for synthesis of calcium carbonate (aragonite) nanoparticles from cockle shell. Powder Technology :70-75 (IF2.08) Kh Nurul Islam, A.B.Z. Zuki, M.E. Ali, Mohd Zobir Bin Hussein, M.M. Noordin, M.Y. Loqman, M.A. Hakim and Sharida Bee Abd Hamid (2012). Facile synthesis of calcium carbonate nanoparticles from cockle shells. Journal of Nanomaterials 201, doi:10.1155/2012/534010 (IF1.376) Kh Nurul Islam, Md Zuki Bin Abu Bakar, Mustapha M. Noordin, Mohd Zobir Bin Hussein, Norshazlirah Shazlyn Bte Abd Rahman and Md Eaqub Ali (2011). Characterisation of calcium carbonate and its polymorphs from cockle shells (Anadara granosa). Powder Technology 213:188-191 (IF2.08) Latif, I.K., Karim, A.J., Zuki, A.B.Z., Zamri-Saad, M., Niu, J.P. & Noordin, M.M. (2011). Efficacy of Nigella sativa in alleviating benzo(a)pyrene-induced immunotoxicity in broilers. Histol. Histopath. 26: 699-710. (IF 2.502) Abdollahi M, ABZ Zuki, YM Goh, Rezaeizadeh A and MM Noordin (2011). The Effects of Momordica Charantia on Pancreatic Histopathological Changes Associated with Streptozotocin-Induced Diabetes in Neonatal Rats. Histology and Histpathology, 26:13-21 (IF2.502) MZ Rozaini, ABZ Zuki, N Yusof, MM Noordin and MNH Abdullah (2011). Sea cucumber (Stichopus hermanii) based hydrogel to treat burn wounds in rats. Journal of Biomedical Material Research Part B. 98B(1):30-37 (IF2.220)